I feel like the Billy Crystal character in The Princess Bride - and thank you so much for bringing up such a painful subject...
The tourney is always a crapshoot - one off game and you're through. Yes, we have fallen victim to the dreaded 12-5 matchup twice in the last 4 tourneys. I'll just say "Middle Tenn St." to the Gopher fan. In 2021, we were a 9 seed and met the eventual national champ in round 2, so no shame there. The 2022 one was very sad because it was in Milwaukee and our starting PG (Chucky Hepburn, now starring at Louisville) got injured at the beginning of the second half, didn't return, and that was that. Even if they had managed to get past ISU, they were toast without having Chucky's services on that team.
It has been a while since they made it to the second weekend - 2017, when they made it as an 8-seed after upsetting #1 overall seed Villanova in the second round (an extremely painful loss to Florida in the next round on a buzzer beater in OT). 2020 would have been interesting because they were on a big roll heading into the conference tournament as the 1-seed and 8 wins in a row before everything got shut down.